Endocrine Abstracts

In women, the anti-Mullerian hormone (AMH) is secreted by the granulosa cells of the growing follicles. Its assay is therefore strongly correlated with the antral follicular count and represents a reliable marker of the ovarian reserve. It also has the advantage of being very reproducible since it has little intra- and inter-cyclic variation. However, it seems to be a good quantitative reflection of the ovarian reserve but not qualitative. This drawback does not make this assa...

Background: The prevalence of the metabolic syndrome (MS) is notably higher in patients with PCOS than in the general population. Presumably, this prevalence increases as a function of age but the subgroups of patients less than 20 yr. old studied so far are small.Design: In order to further document this issue, we have selected for this study 498 patients with PCOS aged 12.5–38 yr (Rotterdam definition) and 188 control women aged 15.5–38.5 yr,...

Objective: To emphasize the difficulties to distinguish between uterine agenesis and extreme uterine hypotrophy in the context of primary amenorrhea with delayed puberty.Patients and methods: Among adolescents who consulted our center because of primary amenorrhea, from 1997 to 2005, three patients were referred for a suspicion of Mayer-Rokitansky-Kuster-Hauser Syndrome, after ultrasonography had failed visualizing the uterus. The 3 patients underwent en...

Objective: To determine the frequency of mutations of the gonadotropin-releasing hormone receptor (GnRHR) and of the G protein-coupled receptor 54 (GPR54) genes in normosmic idiopathic hypogonadotropic hypogonadism patients (IHH).Methods: In a retrospective study we analysed the GnRHR and the GPR54 genes of 327 IHH patients including 105 females (36.5%) and 183 males (63.5%). Among the index cases (288 siblings) 267 were sporadic form (92.7...